RPE65 antibody

Catalog No. ABIN6572041

This anti-RPE65 antibody is a Rabbit Polyclonal antibody detecting RPE65 in WB. Suitable for Human, Rat and Mouse.

Quick Overview for RPE65 antibody (ABIN6572041)

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPE65 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RPE65 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human RPE65

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RPE65

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Alternative Name: RPE65

Background:

Synonyms: All-trans-retinyl-palmitate hydrolase,LCA 2,LCA2,Leber congenital amaurosis ,mRPE 65,mRPE65,p63,rd 12,rd12,Retinal pigment epithelium specific 61 kDa protein,Retinal pigment epithelium specific 65 kDa protein,Retinal pigment epithelium specific protein ,Retinal pigment epithelium specific protein 65  kDa,Retinal pigment epithelium-specific 65 kDa protein,Retinitis pigmentosa 20 ,Retinoid isomerohydrolase,Retinol isomerase,RP 20,RP20,RPE 65,RPE65,RPE65,sRPE 65,sRPE65

Background: This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.

Molecular Weight:

Observed_MW: 61kDa

Calculated_MW: 60kDa

Gene ID: 6121

UniProt: Q16518